Yes, you can get chickenpox a second time, though it is uncommon.1
Why a Second Infection Can Happen
- Lifelong Immunity: For most people, a single infection or full vaccination provides lifelong protection against the varicella-zoster virus.12
- Weakened Immune Systems: A second case is more likely if your immune system was suppressed during the first infection or is currently weakened (such as from chemotherapy, long-term steroid use, or a medical condition).12
- Mild First Case: If the first infection happened when you were a baby under 6 months old or was very mild, your body may not have built a strong immune memory.1
- Misdiagnosis: The first rash might not have been chickenpox at all, meaning the "second" time is actually the first actual infection.12
Chickenpox vs. Shingles
Many people who think they have chickenpox a second time actually have shingles:1
- Chickenpox causes an itchy, widespread rash of 250 to 500 blisters scattered across the entire body.
- Shingles is caused by the same virus, which stays dormant in your nerve cells after your first chickenpox infection and reactivates later in life. It usually shows up as a painful, burning rash in a localized band or patch on one side of the body or face.123
You can check official guidance on symptoms and management via the NHS Chickenpox Guide or read the CDC About Chickenpox overview.12To help me give you more relevant information, could you share:
- Who is experiencing the symptoms (an adult or a child)?
- Is the rash all over the body or localized to one side?
The answer also showed 1 image, not reproduced here.


